畜牧兽医学报 ›› 2019, Vol. 50 ›› Issue (1): 1-13.doi: 10.11843/j.issn.0366-6964.2019.01.001

• 综述 • 上一篇    下一篇

mRNA中N6-甲基腺苷修饰及其在动物中的研究进展

卢曾奎1,2, 张利平2, 李青1, 刘恩民1, 杜立新1, 储明星1*, 魏彩虹1*   

  1. 1. 中国农业科学院北京畜牧兽医研究所, 北京 100193;
    2. 甘肃农业大学动物科学技术学院, 兰州 730070
  • 收稿日期:2018-05-24 出版日期:2019-01-23 发布日期:2019-01-23
  • 通讯作者: 储明星,主要从事动物遗传育种研究,E-mail:mxchu@263.net;魏彩虹,主要从事动物分子育种研究,E-mail:weicaihong@caas.cn
  • 作者简介:卢曾奎(1990-),男,甘肃民勤人,博士生,主要从事绵羊分子遗传育种研究,E-mail:15294157518@163.com
  • 基金资助:

    国家肉羊产业技术体系项目(CARS-38);国家自然科学基金(31672380)

N6-methyladenosine Modification in mRNA and Its Research Advance in Animals

LU Zengkui1,2, ZHANG Liping2, LI Qing1, LIU Enmin1, DU Lixin1, CHU Mingxing1*, WEI Caihong1*   

  1. 1. Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    2. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China
  • Received:2018-05-24 Online:2019-01-23 Published:2019-01-23

摘要:

N6-甲基腺苷(m6A)修饰是动物RNA修饰中最丰富的一种,其受甲基转移酶、脱甲基酶和m6A结合蛋白的动态调控。mRNA中m6A修饰可以调节大多数RNA代谢过程以及在动物体内发挥重要的生理作用。本文主要介绍了动物mRNA中m6A修饰的分布与表达、检测方法、甲基化代谢相关酶及其生理功能的研究进展,并对目前m6A修饰研究中存在的问题或挑战进行展望,为进一步研究m6A修饰提供参考。

Abstract:

The N6-methyladenosine (m6A) modification is the most abundant RNA modification in animals, and is dynamically regulated by methyltransferase, demethylase and m6A binding protein. In mRNA, m6A modification can regulate most RNA metabolism processes and play an important physiological role in animals. In this review, the research progress of distribution and expression, detection methods, enzymes related to methylation metabolism and their physiological functions of m6A modification in animals are well introduced. Besides, the existing problems or challenges in the current m6A modification research are prospected in the present study, which will provide reference for further study on m6A modification.

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